3280 may refer to:
A.D. 3280, a year in the 4th millennium CE 3280 BC, a year in the 4th millennium BCE 3280, a number in the 3000 (number) range
Roads numbered 3280 Louisiana Highway 3280, a state highway Texas Farm to Market Road 3280, a state highway County Road 3280 (Walton County, Florida)
Other uses 3280 Grétry, an asteroid in the Asteroid Belt, the 3280th asteroid registered
See also
, a WWI U.S. Navy cargo ship