Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.
Ilya Ivashka was the defending champion, but lost in the third round to Marc-Andrea Hüsler.
Seeds All seeds receive a bye into the second round.
Draw
Finals
Top half Section 1
Section 2
Bottom half Section 3
Section 4
Qualifying Seeds
Qualifiers
Lucky losers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
References
External links Main draw Qualifying draw