Estupiñán is a Spanish surname. Notable people with the surname include:
Footballers Alfonso Estupiñán (born 1948), Costa Rican footballer Ítalo Estupiñán (1952–2016), Ecuadorian footballer Javier Estupiñán (born 1984), Colombian footballer Óscar Estupiñán (born 1996), Colombian footballer Pervis Estupiñán (born 1998), Ecuadorian footballer Víctor Estupiñán (born 1988), Ecuadorian footballer
Other Ana María Estupiñán (born 1992), Colombian actress and singer Francisco Estupiñán Heredia, Colombian politician and banker Nelson Estupiñán Bass (1912–2002), Ecuadorian novelist Saskia Estupiñán, Ecuadorian dentist, public health official