The Independent Spirit Award for Best Female Performance in a New Scripted Series was one of the annual Independent Spirit Awards to honor an actress who has delivered an outstanding performance in a new scripted series. It was first presented in 2020 with Shira Haas being the first recipient of the award for her role as Esther "Esty" Shapiro in miniseries Unorthodox and the last recipient of the award is Thuso Mbedu for her role as Cora Randall in The Underground Railroad.
In 2022, it was announced that the acting categories would be retired and replaced with two gender neutral categories: Best Lead Performance in a New Scripted Series & Best Supporting Performance in a New Scripted Series.
Winners and nominees 2020s YearNomineesShowRoleNetwork 2020 Shira Haas Unorthodox Esther "Esty" Shapiro Netflix Elle Fanning The Great Catherine the Great HuluAbby McEnany Work in Progress Abby ShowtimeMaitreyi Ramakrishnan Never Have I Ever Devi Vishwakumar Netflix Jordan Kristine Seamón We Are Who We Are Caitlin Poythress / Harper HBO2021 Thuso Mbedu The Underground Railroad Cora Randall Prime VideoDeborah Ayorinde Them: Covenant Livia "Lucky" Emory Prime Video Jasmine Cephas Jones Blindspotting Ashley Rose Starz Jana Schmieding Rutherford Falls Reagan Wells Peacock Anjana Vasan We Are Lady Parts Amina Channel 4
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