Orfanidis is a surname. Notable people with the surname include:

Lazaros Orfanidis (born 1995), Greek footballer Marios Orfanidis (born 1940), Cypriot footballer Petros Orfanidis (born 1996), Greek footballer

See also Georgios Orphanidis (1859–1942), Greek sports shooter Orphanides, surname