The Women's 100 metre backstroke competition at the 2022 World Aquatics Championships was held on 19 and 20 June 2022.

Records Prior to the competition, the existing world and championship records were as follows.

Results Heats The heats were started on 19 June at 09:00.

Rank Heat Lane Name Nationality Time Notes 1 3 4 Regan Smith Q 2 4 4 Kylie Masse Q 3 5 5 Claire Curzan Q 4 5 6 Wan Letian Q 5 4 5 Kira Toussaint Q 6 4 6 Emma Terebo Q 7 5 3 Peng Xuwei Q 8 4 2 Medi Harris 1:00.03 Q 9 3 5 Margherita Panziera 1:00.40 Q 10 3 3 Maaike de Waard 1:00.46 Q 11 5 1 Silvia Scalia 1:00.77 Q 12 5 7 Lee Eun-ji 1:00.78 Q 13 3 6 Paulina Peda 1:00.83 Q 14 4 0 Hanna Rosvall 1:00.99 Q 15 3 7 Mimosa Jallow 1:01.01 Q 16 5 2 Analia Pigrée 1:01.13 Q 17 4 3 Taylor Ruck 1:01.14 18 4 7 Simona Kubová 1:01.19 19 3 2 Katalin Burián 1:01.26 20 5 8 Theodora Drakou 1:01.59 21 3 1 Stephanie Au 1:01.62 22 4 8 Aviv Barzelay 1:01.65 23 3 8 Andrea Berrino 1:02.13 24 4 1 Gabriela Georgieva 1:02.86 25 5 9 Olivia Nel 1:02.95 26 2 4 Jimena Leguizamón 1:03.16 27 2 5 Danielle Titus 1:03.79 28 3 0 Xenia Ignatova 1:03.92 29 5 0 Aleksa Gold 1:03.95 30 2 1 Mia Blaževska Eminova 1:04.11 NR 31 2 3 Elizabeth Jiménez 1:04.15 32 2 8 Andrea Becali 1:04.72 33 3 9 Donata Katai 1:04.80 34 2 2 Carolina Cermelli 1:05.16 35 2 6 Ridima Veerendrakumar 1:05.41 36 4 9 Hsu An 1:05.50 37 2 7 Masniari Wolf 1:06.70 38 1 6 Noor Taha 1:09.28 39 1 4 Enkh-Amgalangiin Ariuntamir 1:10.31 40 2 0 Jamie Joachim 1:12.76 41 1 3 Aynura Primova 1:13.05 42 2 9 Jennifer Harding-Marlin 1:16.28 43 1 5 Aishath Sausan 1:18.76 5 4 Kaylee McKeown

Semifinals The semifinals were started on 19 June at 18:56. Rank Heat Lane Name Nationality Time Notes 1 2 4 Regan Smith 57.65 Q 2 1 4 Kylie Masse 58.57 Q 3 2 5 Claire Curzan 58.96 Q 4 2 3 Kira Toussaint 59.16 Q 5 1 6 Medi Harris 59.61 Q 6 1 5 Wan Letian 59.63 Q 7 2 6 Peng Xuwei 59.96 Q 8 1 3 Emma Terebo Q 9 1 2 Maaike de Waard 10 2 2 Margherita Panziera 11 1 7 Lee Eun-ji 11 2 7 Silvia Scalia 13 2 8 Mimosa Jallow 14 1 1 Hanna Rosvall 15 2 1 Paulina Peda 16 1 8 Analia Pigrée

Final The final was held on 20 June at 18:51.

Rank Lane Name Nationality Time Notes 4 Regan Smith 58.22 5 Kylie Masse 58.40 3 Claire Curzan 58.67 4 7 Wan Letian 59.77 5 8 Emma Terebo 59.98 6 6 Kira Toussaint 59.99 7 1 Peng Xuwei 7 2 Medi Harris

References