The 10th Annual Interactive Achievement Awards was the 10th edition of the Interactive Achievement Awards, an annual awards event that honored the best games in the video game industry during 2006. The awards were arranged by the Academy of Interactive Arts & Sciences (AIAS), and were held at the Hard Rock Hotel and Casino in Las Vegas, Nevada on . It was also held as part of the Academy's 2007 D.I.C.E. Summit, and was hosted by stand-up comedian Jay Mohr.

The original nomination package listed "Cellphone Game of the Year", but the finalists were listed for "Mobile Game of the Year". The nomination package also features a genre category of "Casual Game of the Year", but there were not any finalists named for this category. Instead, finalists were listed for "Downloadable Game of the Year", which was not part of the category listing in the rules & procedures.

Gears of War received the most nominations and won the most awards, including "Overall Game of the Year". Microsoft Game Studios and Nintendo tied for having the most nominations, with Microsoft winning the most awards. Electronic Arts had the most nominated games, and tied with Microsoft and Nintendo for having the most award-winning games. Nintendo EAD was the only developer with more than one award-winning game.

Dani Bunten was inducted posthumously into the Academy of Interactive Arts & Sciences Hall of Fame. Nintendo of America founders Minoru Arakawa and Howard Lincoln also became the first recipients of the "Lifetime Achievement Award".

Winners and Nominees Winners are listed first, highlighted in boldface, and indicated with a double dagger ().

Game of the Year awards Gears of War (Epic Games, Microsoft Game Studios) — Rod Fergusson, Michael Capss, Cliff Bleszinski Guitar Hero II (Harmonix, RedOctane) — John Tam, Daniel Sussman, Josh Randall The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Todd Howard The Legend of Zelda: Twilight Princess (Nintendo EAD) — Shigeru Miyamoto, Eiji Aonuma, Satoru Iwata Wii Sports (Nintendo EAD) — Keizo Ohta, Takayuki Shimamura, Katsuya Eguchi, Yoshikazu Yamashita, Satoru IwataThe Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Todd Howard Age of Empires III: The WarChiefs (Ensemble Studios, Microsoft Game Studios) — Wally Wachi, Sandy Petersen Battlefield 2142 (DICE, Electronic Arts) Company of Heroes (Relic Entertainment, THQ) — John Johnson, Sean Dunn Prey (Human Head Studios, 2K Games) — Timothy S. Gerrtisen, Ted Halstead, Chris RhinehartGears of War (Epic Games, Microsoft Game Studios) — Rod Fergusson, Michael Capss, Cliff Bleszinski Guitar Hero II (Harmonix, RedOctane) — John Tam, Daniel Sussman, Josh Randall The Legend of Zelda: Twilight Princess (Nintendo EAD) — Shigeru Miyamoto, Eiji Aonuma, Satoru Iwata Viva Piñata (Rare, Microsoft Game Studios) — Gregg Mayles Wii Sports (Nintendo EAD) — Keizo Ohta, Takayuki Shimamura, Katsuya Eguchi, Yoshikazu Yamashita, Satoru IwataBrain Age: Train Your Brain in Minutes a Day! (Nintendo SPD) — Shinya Takahashi, Kouichi Kawamoto, Noriko Kitamura, Masamuichi Sakaino, Shinji Kitahara, Yoshinori Katsuki, Tadashi Matsushita, Masaru Nishida Elite Beat Agents (iNiS, Nintendo) — Shinya Saito, Masako Harada, Keiichi Yano Lego Star Wars II: The Original Trilogy (Traveller's Tales, LucasArts) — Loz Doyle, Jon Burton, James Cunliffe LocoRoco (SCE Japan Studio) — Tsutomu Kouno New Super Mario Bros. (Nintendo EAD) — Hiroyuki Kimura, Shigeyuki Asuke, Massanao Arimoto

Outstanding Innovation in Gaming Wii Sports (Nintendo EAD) — Katsuya Eguchi, Satoru Iwata, Keizo Ohta, Takayuki Shimamura, Yoshikazu Yamashita, Kouichi Kawamoto, Noriko Kitamura, Masamuichi Sakaino, Shinji Kitahara, Yoshinori Katsuki, Tadashi Matsushita, Masaru Nishida Brain Age: Train Your Brain in Minutes a Day! (Nintendo SPD) — Shinya Takahashi, Kouichi Kawamoto, Masaru Nishida Gears of War (Epic Games, Microsoft Game Studios) — Rod Fergusson, Michael Capss, Keizo Ohta, Takayuki Shimamura, Cliff Bleszinski LocoRoco (SCE Japan Studio) — Tsutomu Kouno Viva Piñata (Rare, Microsoft Game Studios) — Gregg Mayles

Craft awards Wii Sports (Nintendo EAD) — Keizo Ohta, Takayuki Shimamura, Yoshikazu Yamashita Brain Age: Train Your Brain in Minutes a Day! (Nintendo SPD) — Kouichi Kawamoto Company of Heroes (Relic Entertainment, THQ) — Josh Mosqueira, John Johnson, Sean Dunn The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Todd Howard The Legend of Zelda: Twilight Princess (Nintendo EAD) — Eiji Aonuma, Kouichi Kawamoto, Noriko Kitamura, Masamichi Sakaino, Shinji Kitahara, Yoshinori Katsuki, Tadashi Matsushita, Masaru NishidaThe Legend of Zelda: Twilight Princess (Nintendo EAD) — Mitsuhiro Takario, Aya Kyogoku, Yusuke Nakano, Satomi Asakawa, Takahiro Watanabe 24: The Game (SCE Cambridge Studio, 2K Games) — Duppy Demetrius, Chris Sorrell, Robert Hill, Candice Teo, Paul Gadd Dreamfall: The Longest Journey (Funcom, Aspyr) — Ragnar Tørnquist, Dag Scheve Saints Row (Volition, THQ) — Steve Jaros, Tommy Stanton, Douglas Carrigan Sam & Max Episode 1: Culture Shock (Telltale Games) — Dave Grossman, Brendan Ferguson, Steve Purcell, David Bogan, Julian KwasneskiGears of War (Epic Games, Microsoft Game Studios) — Aaron Herzog, Jay Hosfelt, Jerry O'Flaherty Daxter (Ready at Dawn, Sony Computer Entertainment) — Ru Weerasuriya, Jerome de Menou Fight Night Round 3 (EA Chicago) — Alan Cruz, Andy Konieczny Lego Star Wars II: The Original Trilogy (Traveller's Tales, LucasArts) — Jeremy Pardon Rayman Raving Rabbids (Ubisoft Montpellier) — Patrick BodardGears of War (Epic Games, Microsoft Game Studios) — Jerry O'Flaherty, Chris Perna Call of Duty 3 (Treyarch, Activision) Final Fantasy XII (Square Enix) — Akihiko Yoshida, Hideo Minaba Tom Clancy's Rainbow Six: Vegas (Ubisoft Montreal) — Olivier Leonardi, Jeffrey Giles Viva Piñata (Rare, Microsoft Game Studios) Guitar Hero II (Harmonix, RedOctane) — Eric Brosius FIFA 07 (EA Canada) — Joe Nickolis Marc Ecko's Getting Up: Contents Under Pressure (The Collective, Atari) — Marc Ecko, Sean "Diddy" Combs Scarface: The World Is Yours (Radical Entertainment, Sierra Entertainment) — Rob Bridgett SingStar Rocks! (SCE London Studio) — Alex Hackford, Sergio PimentelLocoRoco (SCE Japan Studio) — Nobuyuki Shimizu, Kemmei Adachi Black (Criterion Games, Electronic Arts) — Chris Tilton, Michael Giacchino Call of Duty 3 (Treyarch, Activision) — Joel Goldsmith The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Jeremy Soule Tom Clancy's Splinter Cell: Double Agent (Ubisoft Shanghai) — Michael McCannCall of Duty 3 (Treyarch, Activision) — Jerry Berlongieri Company of Heroes (Relic Entertainment, THQ) — John Tenant, Glen Jamison, Crispin Hands The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Mark Lampert Tom Clancy's Ghost Recon Advanced Warfighter (Red Storm Entertainment, Ubisoft Paris) — Alexandre Carlotti, Emmanuel Gouvemaire Tom Clancy's Splinter Cell: Double Agent (Ubisoft Shanghai) — Zhang Lei, Roman HisWii Sports (Nintendo EAD) — Emi Tomita, Takako Ishii, Masanobu Sato, Yoshifumi Masaki Company of Heroes (Relic Entertainment, THQ) — Josh Mosqueira, Paul Mitchell, Shelby Hubick Gears of War (Epic Games, Microsoft Game Studios) — Cliff Bleszinski, Ray Davis The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Todd Howard, Guy Carver, Craig Walton The Legend of Zelda: Twilight Princess (Nintendo EAD) — Eiji Aonuma, Tokhiko Toyoda, Mei Ide, Kazuaki Morita, Yoshiyuki OyamaGears of War (Epic Games, Microsoft Game Studios) — Cliff Bleszinski, Ray Davis Battlefield 2142 (DICE, Electronic Arts) — Marcus Nileson Call of Duty 3 (Treyarch, Activision) — David Vonderhaar, Dan Bunting Chromehounds (FromSoftware, Sega) — Toshifumi Nabeshima, Yusuke Ebata Tom Clancy's Ghost Recon Advanced Warfighter (Red Storm Entertainment, Ubisoft Paris) — Christian Allen, Clark GibsonGears of War (Epic Games, Microsoft Game Studios) — Tim Sweeney, Unreal Engine Team Call of Duty 3 (Treyarch, Activision) — Mike Anthony, David King Company of Heroes (Relic Entertainment, THQ) — Drew Dunlop, Ian Thompson Resistance: Fall of Man (Insomniac Games, Sony Computer Entertainment) — Jonny Garrett Viva Piñata (Rare, Microsoft Game Studios) — Will Bryan, Al Hastings, Mark Lee, Rob Wyatt, Mike Day, Reddy Sambavaram, John Morgan, Jeff Chan, Sam Christiansan

Character Performance Awards John DiMaggio as Marcus Fenix, Gears of War (Epic Games, Microsoft Game Studios) — Written by Susan O'Connor Gerry Rosenthal as Jimmy Hopkins, Bully (Rockstar Vancouver) — Written by Dan Houser Max Casella as Daxter, Daxter (Ready at Dawn, Sony Computer Entertainment) — Written by Dan Arey Lego Han Solo, Lego Star Wars II: The Original Trilogy (Traveller's Tales, LucasArts) — Written by Jeremy Pardon Michael Ironside as Sam Fisher, Tom Clancy's Splinter Cell: Double Agent (Ubisoft Shanghai) — Written by Richard DanskyLouise Ridgeway as Leafos, Viva Piñata (Rare, Microsoft Game Studios) Maine Anders as Christy Martin, Bully (Rockstar Vancouver) — Written by Dan Houser Brenda Strong as Mary Alice Young, Desperate Housewives: The Game (Liquid Entertainment, Buena Vista Games) — Story and dialog by Greg Hillegas, Charley Price, and Scott Sanford Tobis; additional dialog by Vernon Dunmore and Eric Heine Tia Carrere as Lin, Saints Row (Volition, THQ) — Written by Steve Jaros Lynda Carter, The Elder Scrolls IV: Oblivion (Bethesda Game Studios, 2K Games) — Written by Ken Rolston

Genre awards Gears of War (Epic Games, Microsoft Game Studios) — Rod Fergusson, Michael Capss, Cliff BleszinskiDaxter (Ready at Dawn, Sony Computer Entertainment) — Marc Turndorf, Didier Malenfant, Ru Weerasuriya Saints Row (Volition, THQ) — Jacques Hennequet, Chris Stockman The Legend of Zelda: Twilight Princess (Nintendo EAD) — Shigeru Miyamoto, Eiji Aonuma, Satoru Iwata Tom Clancy's Splinter Cell: Double Agent (Ubisoft Shanghai) — Domitille Doat, Daniel Ray, Arnaud Carette | valign="top" width="50%" |LocoRoco (SCE Japan Studio) — Tsutomu KounoKim Possible: What's the Switch (Artificial Mind and Movement, Buena Vista Games) — Shannon Monroe, Nathalie Jasmine, Stephen Jarrett, David Osborne Over the Hedge (Edge of Reality, Activision) — Steve Rosenthal, Lara Lyn McWilliams, Thomas Coles Pokémon Mystery Dungeon: Blue Rescue Team and Red Rescue Team (Chunsoft, Nintendo, The Pokémon Company) — Koichi Nakamura, Seiichiro Nagahata The Legend of Spyro: A New Beginning (Krome Studios, Sierra Entertainment) — Greg Goodrich, John Welsh, Chris Wilson |- | valign="top" width="50%" |Tom Clancy's Rainbow Six: Vegas (Ubisoft Montreal) — Chadi Lebbos, Alexandre Parizeau, Maxime BelandBlack (Criterion Games, Electronic Arts) — Alex Ward Half-Life 2: Episode One (Valve, Electronic Arts) Resistance: Fall of Man (Insomniac Games, Sony Computer Entertainment) Prey (Human Head Studios, 2K Games) — Timothy S. Gerrtisen, Ted Halstead, Chris Rhinehart | valign="top" width="50%" |Fight Night Round 3 (EA Chicago) — Kudo Tsunoda, Keith Morton, Darren BennettMortal Kombat: Armageddon (Midway Games) — John Padlasek, Ed Boon Tekken: Dark Resurrection (Eighting, Namco Bandai) — Hajime Nakatani, Haruki Suzaki, Naohiro Hayashi WWE SmackDown! vs. Raw 2007 (Yuke's, THQ) — Hiromi Furuta, Tokuichi Kitaguchi, Taku Chihaga |- | valign="top" width="50%" |Guitar Hero II (Harmonix, RedOctane) — John Tam, Daniel Sussman, Josh RandallBrain Age: Train Your Brain in Minutes a Day! (Nintendo SPD) — Shinya Takahashi, Kouichi Kawamoto, Satoru Iwata Lego Star Wars II: The Original Trilogy (Traveller's Tales, LucasArts) — Loz Doyle, Jon Burton, James Cunliffe Rayman Raving Rabbids (Ubisoft Montpellier) — Pierre-Arnaud Lambert, Jaques Exertier Viva Piñata (Rare, Microsoft Game Studios) — Gregg Mayles | valign="top" width="50%" |Guild Wars Nightfall (ArenaNet, NCSoft) — Jay AdamsAuto Assault (NetDevil, NCSoft) — Steven Snow, Scott Brown Dungeons & Dragons Online: Stormreach (Turbine, Atari) — Judith Hoffman, Ken Troop