Rhys ap Gruffudd (c.1132–1197) was a Prince of Dehubarth in South Wales.
It may also refer to:
Sir Rhys ap Gruffudd (c.1283–1356), South Wales nobleman and soldier Rhys ap Gruffudd (rebel) (1508–1531), nobleman and rebel executed by Henry VIII
See also Rhys Gruffydd (c.1513–1580), Member of Parliament for Caernarfon