The women's singles of the 2021 I.ČLTK Prague Open tournament was played on clay in Prague, Czech Republic.
Tamara Korpatsch was the defending champion, but chose not to participate.
Jule Niemeier won the title, starting from qualifications, defeating Dalma Gálfi in the final, 6–4, 6–2.
Seeds
Draw
Finals
Top half
Bottom half
References
External links Main Draw on ITF website