Karpen is a village in Albania. Karpen may also refer to:

People with the surname Andrew Karpen (1966–2025), American independent film distributor and movie executive Henry C. Karpen (1868–1936), American politician Judy Karpen (born 1953), American astrophysicist Nicolae Vasilescu-Karpen (1870–1964), Romanian engineer and physicist Richard Karpen (born 1957), American electronic music composer

Other Anton and Mary Agnes Karpen House, a historic building in South Dakota Karpen House, a historic building in New York S. Karpen & Bros., American furniture manufacturer