Enrile is a surname. Notable people with the surname include:
Arturo Enrile (1940–1998), Filipino politician, cousin of Juan Jack Enrile (born 1958), Filipino politician, son of Juan Joaquín Ezpeleta Enrile (1788–?), Spanish politician and army general Juan Ponce Enrile (1924–2025), Filipino politician and lawyer Pasqual Enrile y Alcedo (1772–1836), Spanish governor-general of the Philippines Ronjay Enrile (born 1982), Filipino basketball player Sally Ponce Enrile, Filipino politician, wife of Jack