Agwo Facula is a bright, irregular depression on the surface of Mercury, located at 22.4° N, 213.7° W, in southwestern Caloris Planitia. It was named by the IAU in 2018. Agwo is the Igbo word for snake. The depression is the site of multiple volcanic explosions.TIME TO VENT, MESSENGER Featured Image Database, 3 January 2012.

Agwo Facula is near the southwestern rim of the Caloris basin. Agwo Facula is immediately northeast of Abeeso Facula.

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