Ayotte is a surname. Notable people with the surname include:
Kelly Ayotte (born 1968), governor of New Hampshire and former United States senator Leo Ayotte (1909–1976), artist Mark Ayotte (born 1964), referee
See also Ayotte Drums, drum producer Ayotte v. Planned Parenthood of Northern New England, a 2006 case in the US Supreme Court on the subject of abortion