Musoke is a surname. Notable people with the surname include:
Allan Musoke (born 1980), Ugandan rugby union player Benjamin Musoke (born 1976), Ugandan cricketer Damalie Nagitta-Musoke, Ugandan academic Deogratias Musoke (born 1949), Ugandan boxer Elizabeth Musoke, Ugandan justice of the Court of Appeal of Uganda
Kintu Musoke, (born 1938), Ugandan politician Maria Musoke (born 1955), Ugandan information scientist Mary Musoke, Ugandan table tennis player Nico Musoke (born 1986), Swedish mixed martial artist Sarah Kiyingi Musoke (born 1960), Ugandan politician Theresa Musoke (born 1945), Ugandan-Kenyan painter and visual artist