Santa Rosa Cathedral or Cathedral of Santa Rosa, or variants thereof, may refer to:

Santa Rosa Cathedral (California), United States Santa Rosa Cathedral (Carúpano), Venezuela Santa Rosa Cathedral (La Pampa), Argentina; see Roman Catholic Diocese of Santa Rosa in Argentina Santa Rosa de Osos Cathedral, Colombia Santa Rosa de Copán Cathedral, Honduras

See also Saint Rose (disambiguation) or Santa Rosa Santa Rosa (disambiguation) St. Rose's Church (disambiguation)