Sakalis is a Greek surname (Σακαλής). Notable people with the surname include:
Sofia Sakalis, Australian soccer player Roni Sakalis, alias of Rony Seikaly, Lebanese-American basketball player, while he was playing in Greece Dimitra Sakalis, Greek screenwriter, e.g., of Mavra Mesanychta Georgios Sakalis, Minister of State (Greece) in exile (1944)