Liquid-liquid phase separation (LLPS) is well defined in the Biomolecular condensate page.
LLPS databases cover different aspects of LLPS phenomena, ranging from cellular location of the Membraneless Organelles (MLOs) to the role of a particular protein/region forming the condensate state. These databases contain manually curated data supported by experimental evidence in the literature and can include related features as presence of protein disorder, low complexity, post-translational modifications, experimental details, phase diagrams, among others. +Table 1DatabaseCreatedRecordsDescription - Type of dataPhaSepDB2.020192957Aims at collecting proteins that were found in membraneless organelles (MLOs), and organizes its entries according to MLO location. All entries can be classified into three groups depending on the quality of annotation: (i) Reviewed, verified by PhaSepDB curators, (ii) UniProtKB reviewed, pulled from UniProtKB, and (iii) high-throughput, identified by high-throughput experiments - MLO localization/associationMloDisDB2021771Manually curated database, developed by the same research group of PhaSepDB, but focusing on the association between MLOs and diseases - MLO localization/association and diseasesPhaSePro2019121Manually curated database of LLPS drivers, solely based on experimentally verified cases of LLPS - Drivers/ScaffoldsLLPSDB20191182Collection of in vitro LLPS experiments detailing the outcome and parameters of thousands of experiments -ExperimentsDrLLPS20199285Database of LLPS proteins from nine model organisms - Clients, regulators, drivers/scaffolds
See also Biomolecular condensate
MobiDB database
Intrinsically disordered proteins
DisProt database
References