Lesperance, or Lespérance, is a surname. It may refer to:
Lesperance David Lesperance, United States Army major general Ellen Lesperance (born 1971), American artist and educator, known for her paintings Matt Lesperance (born 1987), American wheelchair basketball player Pete Lesperance, Canadian musician and producer Jeffrey Lesperance, United States Army Colonel
Lespérance Sylvie Lespérance (1954–2006), Canadian politician from Quebec Zotique Lespérance (1910–2006), Canadian sportswriter
See also L'Esperance (disambiguation)