Cottonwood Creek is a stream in Oklahoma that flows from rural Canadian County through portions of Logan County until it reaches its mouth at the Cimarron River, northwest of Guthrie.

Significant tributaries of Cottonwood Creek include Chisholm Creek and Deer Creek. Its source is located in rural Canadian County northwest of the city of Piedmont. The stream drains about320 square miles."USGS 07159750 Cottonwood Creek near Seward, OK" Waterdata.usgs.gov Accessed Oct. 26, 2021.

The creek has often caused flooding in Guthrie."Floods in Guthrie, Oklahoma" US Army Corps of Engineers (1970) (Archived at LOC.gov, accessed Oct. 26, 2021)"Guthrie flooding keeps schools, roads closed" News9.com (May 22, 2019)"Recent flood ranks in top 10" GuthriesNewsPage.com (May 22, 2019)[https://www.youtube.com/watch?v=eB4tCHmEsxM "Concerns in Guthrie as Cottonwood Creek on verge of flooding" KOCO News 5 (May 1, 2025)[ (accessed Jan. 18, 2025) It is also the namesake of the Cottonwood Flats festival grounds in Guthrie.McDonnell, Brandy "Oklahoma International Bluegrass Fest continues after death of founder Byron Berline" The Oklahoman (Sept. 28, 2021) Accessed Oct. 26, 2021.

Historic flood levels

+ Record flood crest levels of Cottonwood Creek at Guthrie"Recent flood ranks in top 10" GuthriesNewsPage.com (May 22, 2019) Crest level in feet Date 30.00 10/20/1983 29.60 05/09/1993 29.26 10/02/1959 28.58 05/15/1949 28.09 09/21/1965 27.90 05/28/1987 27.90 06/09/1995 27.40 05/22/2019 27.40 06/01/2013 27.20 09/13/1989

References