Amoss is a surname. Notable people with the surname include:
David Amoss, American tobacco farmer Jim Amoss (born 1947), American journalist, former editor of The Times-Picayune Thomas M. Amoss (born 1961), American thoroughbred horse trainer Ulius Louis Amoss (1895–1961), American intelligence officer William H. Amoss (1936–1997), American politician
See also James M. Amoss Building, a historic commercial building in Wabash, Indiana, United States