Rancho Grande is a municipality in Matagalpa, Nicaragua.
Rancho Grande may also refer to:
Rancho Grande, New Mexico, a census-designated place in Catron County Rancho Grande (film), a 1940 Western film directed by Frank McDonald Rancho Grande (Mexibús), a bus rapid transit station in Nezahualcóyotl, Mexico Rancho Grande Airstrip, in Ensenada, Baja California, Mexico Rancho Grande River, in Santa Catarina, Brazil