Vio is a surname. Notable people with the surname include:

Beatrice Vio (born 1997), Italian fencer Betty Vio (c. 1808–1872), Italian–German opera singer Romano Vio (1913–1984), Italian sculptor Tomás Vio (1921–2001), Argentine basketball player Fabio Vio (born 1949), Chilean diplomat

See also Vio (disambiguation)