Osmeña may refer to:
Sergio Osmeña (1878–1961), President of the Philippines Sergio Osmeña, Zamboanga del Norte, a municipality in the Philippines Sergio Osmeña Jr. (1918–1984), his son, senator John Henry Osmeña (1935–2021), also known as Sonny Osmeña, his grandson, senator Lito Osmeña (Emilio Mario Renner Osmeña Jr, 1938–2021), governor of Cebu, his grandson Serge Osmeña (Sergio de la Rama Osmeña III) (born 1943), senator, his grandson Tomas Osmeña (born 1948), mayor of Cebu City, his grandson Osmeña pearl, made by polishing the shell of a nautilus
See also Osmeña Boulevard, in Cebu City, Philippines Osmeña Highway, in Metro Manila, Philippines Bando Osmeña – Pundok Kauswagan, a Philippines political party