Leimgruber is a surname. Notable people with the surname include:

Darcia Leimgruber (born 1989), Swiss ice hockey player Oskar Leimgruber (1886–1976), Swiss Politician Urs Leimgruber (born 1952), Swiss saxophonist Werner Leimgruber (1934–2025), Swiss footballer Wilhelm Leimgruber, Austrian luger

See also Leimgruber–Batcho indole synthesis, series of organic reactions