QSC may refer to:
Corporations QSC AG, a German telecommunications and DSL provider QSC Audio Products aka Q-SYS, a global audio, video, and control platform manufacturer based in California Queens Surface Corporation, a former bus company in New York City
Colleges Queen's School of Computing, a department of Queen's University in Kingston, Ontario, Canada Quirino State College, former name of Quirino State University in Quirino, Philippines
Other uses QSC, the IATA airport code for São Carlos Airport in Brazil QSC, a radiotelegraphic Q code meaning "are you a cargo vessel" when posed as a question qSc, a portion of the equation defining the pitching moment coefficient of an airfoil Quebec Superior Court, the trial-level superior court of the province of Quebec, Canada Queens Sports Club, a stadium in Bulawayo, Zimbabwe QSC&V (Quality, Service, Cleanliness & Value), a quality benchmark used by McDonald's Corporation QSC supercomputer (2004–2007), a supercomputer at Los Alamos National Laboratory which replaced Blue Mountain (supercomputer)