James or Jim Byrne may refer to:

Politics James A. Byrne (1906–1980), U.S. representative from Pennsylvania James Allen Byrne (1911–1975), Liberal Party member of the Canadian House of Commons James J. Byrne (politician) (1863–1930), American singer and politician from New York

Religion James Byrne (bishop of Toowoomba) (1870–1938), Irish-born priest James Byrne (archbishop of Dubuque) (1908–1996), Roman Catholic prelate who served as archbishop of Dubuque and bishop of Boise James Byrne (dean of Clonfert) (1820–1897), Church of Ireland priest

Sports James Byrne (footballer) (born 1978), Australian rules footballer James Byrne (sailor) (born 1948), Australian Olympic sailor J. F. Byrne (1871–1954), English cricketer; captain of Warwickshire and rugby international Jim Byrne (footballer, born 1880) (1880–1927), Australian rules footballer for Melbourne Jim Byrne (footballer, born 1933), Australian rules footballer for St Kilda Jim Byrne (Gaelic footballer) (1890–?), Irish Gaelic football administrator, referee and player Jim Byrne (dual player) (born 1973), hurling and Gaelic football coach and former player of both sports Jimmy Byrne (born 1941), Irish hurler

Other James Byrne (Irish criminal) (1947/1948–2024), Irish criminal James Byrne (lawyer) (born 1964), American lawyer James Byrne (musician) (1946–2008), Irish traditional musician James Byrne (poet) (born 1977), British poet and editor James Byrne (VC) (1822–1872), Irish recipient of the Victoria Cross James J. Byrne (US Civil War officer) (1841–1880), Irish-American Union Army officer and United States Marshal James Byrne (fl. 1775–1819) of Clone, County Wexford, see List of monumental masons

See also James Burns (disambiguation) James Byrnes (disambiguation)