The 2021–22 season was Manchester United's 30th season in the Premier League and their 47th consecutive season in the top flight of English football.

On 27 August 2021, Cristiano Ronaldo returned to the club from Juventus, 12 years after leaving for Real Madrid in 2009 for a world-record transfer fee.

Manager Ole Gunnar Solskjær began his third full season in charge following a second-place finish the previous season and a loss in the Europa League final. Despite a strong start, he was sacked on 21 November after winning just one league game in seven. First-team coach Michael Carrick took charge as caretaker for three games, after which Ralf Rangnick was appointed interim manager on 3 December and oversaw the team until the end of the season. Erik ten Hag was appointed Solskjær's permanent successor on 21 April and took over following the final game of the campaign.

This was United's fifth consecutive trophyless season, their longest drought since a six-season run between 1968–69 and 1973–74. They recorded their worst points tally in the Premier League era, finishing with just 58 points. Despite this, they placed sixth and qualified for the UEFA Europa League. United were knocked out of the EFL Cup in the third round by West Ham United, and out of the FA Cup in the fourth round by Middlesbrough on penalties. United were eliminated from the UEFA Champions League in the Round of 16 by Atlético Madrid.

Pre-season and friendlies Due to the COVID-19 pandemic, Manchester United did not go on an overseas tour in the 2021–22 pre-season. Instead, they played matches in England, beginning with an away match against Championship side Derby County – managed by United's record goalscorer, Wayne Rooney – on 18 July 2021. Tahith Chong, who was playing despite having agreed to join Birmingham City on loan for the season, scored the first goal in the 18th minute. He was substituted at half-time by Facundo Pellistri, who added a second on the hour mark. Colin Kazim-Richards pulled a goal back for Derby, but United held on to win 2–1. United's next game was against Queens Park Rangers on 24 July. Jesse Lingard opened the scoring in the third minute, but Charlie Austin equalised four minutes later. QPR then scored three goals in the space of eight minutes in the second half to give them a 4–1 lead with half an hour to play. Anthony Elanga pulled a goal back for Manchester United in the 73rd minute, but it was not enough to prevent defeat.

On 28 July, United returned to Old Trafford to play Premier League debutants Brentford. Elanga scored his second goal in two games in the 12th minute, only for Shandon Baptiste to equalise eight minutes later. Andreas Pereira then put United in front again with a volley from 25 yards out that went in off the underside of the crossbar; however, Bryan Mbeumo equalised for Brentford with 12 minutes left to play, and the visitors left with a draw. United were scheduled to play an away game against another Championship club, Preston North End, on 31 July, but the match was cancelled due to a number of suspected positive COVID-19 tests within the Manchester United team. The final pre-season game was at home to fellow Premier League side Everton on 7 August; United were 3–0 up by half-time via goals from Mason Greenwood, Harry Maguire and Bruno Fernandes, before Diogo Dalot scored a fourth in the second half.

DateOpponentsH / AResultF–AScorersAttendance18 July 2021Derby CountyA2–1Chong 18', Pellistri 60'24 July 2021Queens Park RangersA2–4Lingard 3', Elanga 73'28 July 2021BrentfordH2–2Elanga 12', Pereira 50'30,00031 July 2021Preston North EndACancelled7 August 2021EvertonH4–0Greenwood 8', Maguire 15', Fernandes 29', Dalot 90+2'55,000

Premier League Matches The 2021–22 Premier League fixtures were released on 16 June 2021.

The league season started with a home match against Roses rival Leeds United on 14 August 2021. Bruno Fernandes scored a hat-trick, and Mason Greenwood and Fred scored the other two goals in a 5–1 win, as Paul Pogba equalled a Premier League record with four assists. Luke Ayling scored the only goal for the visitors. The following week, United travelled to face Southampton, and went behind on the half-hour mark, when Fred deflected Ché Adams' shot past David de Gea for an own goal. Greenwood equalised 10 minutes into the second half, but United were unable to find a winner and the game finished 1–1, extending United's unbeaten away run to 27 league matches, equalling the record set by Arsenal in 2004. That record was broken the following week, when on 29 August 2021, United travelled to face Wolverhampton Wanderers in the final match before the first international break of the season. Raphaël Varane made his debut following his move from Real Madrid, and provided the assist as Greenwood scored the only goal of the game to secure a 1–0 win.

United's first game after the international break was at home to Newcastle United on 11 September and marked Cristiano Ronaldo's second debut for the club after re-signing from Juventus. It took him until injury time at the end of the first half to open the scoring, turning home the rebound after Newcastle goalkeeper Freddie Woodman spilled a long-range shot from Greenwood. Javier Manquillo equalised for Newcastle in the 56th minute, but Ronaldo restored United's lead six minutes later with a shot through Woodman's legs following a through-ball from Luke Shaw. Fernandes then scored a third with a long-range strike 10 minutes from full time, before Jesse Lingard scored his first goal for the club since August 2020, as United won 4–1 to return to the top of the table. In the next match away to West Ham United on 19 September, United went behind on the half-hour when a shot from Saïd Benrahma was deflected past De Gea off Varane; however, less than five minutes later, Ronaldo scored the equaliser, following up after his original shot was saved by Łukasz Fabiański. A minute from the end of normal time, Lingard put United in front with a curling shot into the top corner from just inside the penalty area, but deep into injury time, West Ham were awarded a penalty after Shaw was deemed to have handled the ball in his own area. Mark Noble was brought on specifically to take the kick, but De Gea dived the right way to make the save; it was his first penalty save in the league since October 2014. United then played host to Aston Villa on 25 September, and lost defenders Harry Maguire and Shaw to injury either side of half-time. The match remained goalless until the 88th minute, when Kortney Hause headed in a corner. The Villa defender then gave away a penalty in injury time when he handled the ball after an Edinson Cavani flick-on; however, Fernandes' shot went over the bar, giving Villa their first win at Old Trafford in any competition since December 2009.

United took the lead just before half-time in their first fixture in October, at home to Everton, when Anthony Martial scored his first club goal since the 9–0 win over Southampton in February; however, Andros Townsend equalised for the visitors 20 minutes into the second half. Yerry Mina thought he had scored the winning goal in the 86th minute, but it was ruled out for offside by the video assistant referee (VAR). Following the international break, United travelled to the King Power Stadium two weeks later to face Leicester City. Greenwood opened the scoring, but Youri Tielemans pulled Leicester level just after the half-hour, before Çağlar Söyüncü put them in front with 12 minutes to go in the match. Marcus Rashford levelled the scores again in his first appearance since the UEFA Euro 2020 final, but Jamie Vardy restored Leicester's lead a minute later and Patson Daka added a fourth in injury time to end United's record-breaking away Premier League unbeaten streak at 29. The following week, United hosted arch-rivals Liverpool; Naby Keïta opened the scoring in the fifth minute, before Diogo Jota doubled the lead eight minutes later. Mohamed Salah scored two more before half-time to put United four goals down at the break for only the second time in a Premier League game, before completing his hat-trick five minutes into the second half. Pogba was then sent off for a two-footed tackle on Keïta as United suffered their worst ever home defeat to Liverpool. With United on the verge of losing three league games in a row for the first time since December 2015, they travelled to play Tottenham Hotspur on 30 October. Playing with five at the back following the return of Varane from injury and with Cavani starting up front alongside Ronaldo, United won the match 3–0. Ronaldo opened the scoring six minutes before half-time before providing an assist for Cavani's first goal of the season almost 20 minutes into the second half, and Rashford completed the scoring four minutes from the end.

November began with Manchester United playing host to their local rivals Manchester City at Old Trafford. Eric Bailly started in place of Varane, who had been injured in the Champions League match against Atalanta four days earlier, and it was the Ivorian defender who opened the scoring, albeit for the away side, as he put João Cancelo's cross into his own net. Bernardo Silva doubled City's lead just before half-time, when Bailly was substituted by Jadon Sancho. City remained the more likely of the two sides to score in the second half, but De Gea was able to keep them out for the remainder of the game, and United went into the international break nine points behind league leaders Chelsea as City won a league match against United for the first time since 24 April 2019. On 20 November 2021, United suffered a 4–1 defeat to newly promoted Watford, leaving the Red Devils seventh in the table. United academy graduate Joshua King opened the scoring before De Gea saved a penalty from Ismaïla Sarr (as well as the original, which had to be retaken for encroachment); however, Sarr did eventually score just before half-time. Donny van de Beek scored his first goal of the season five minutes into the second half, but Maguire was sent off for a second yellow card midway through the period. As United searched for an equaliser, João Pedro and Emmanuel Dennis scored in added time to confirm Watford's victory. It was announced the following day that Solskjær had left his role by mutual consent and that Michael Carrick had replaced him as caretaker manager. In Carrick's first Premier League match in charge, which made him the first English manager to lead United in a league match since Ron Atkinson in November 1986, United visited Chelsea at Stamford Bridge. United opened the scoring after Jorginho miscontrolled a long clearance from Fernandes, allowing Sancho to take advantage of a two-on-one with Édouard Mendy and score his first league goal for United; however, Jorginho made up for his mistake from the penalty spot, after Aaron Wan-Bissaka had fouled Thiago Silva in the penalty area, and the match finished 1–1, making Chelsea still seeking their first league win against United since November 2017.