Guillier is a surname. It may refer to:
Alejandro Guillier Álvarez (born 1953), Chilean sociologist, television and radio journalist and politician Georges Guillier (1920–1983), French racing cyclist Lucien Guillier (1926–2019), French Olympian, discus thrower, shot putter
See also Guilliers (Breton: Gwiler-Porc'hoed), a commune in the Morbihan department of Brittany in north-western France