Frosini is a surname. Notable people with the surname include:
Alessandro Frosini (born 1972), Italian basketball player Deanna Milvia Frosini (1940–2021), Italian actress and painter Francesco Frosini (1654–1733), archbishop of Pisa Kyra Frosini (1773–1800), Greek socialite Luciano Frosini (1927–2017), Italian racing cyclist Pietro Frosini (1885–1951), Italian accordionist and vaudeville performer