Santo is a masculine given name which may refer to:
People Santo Biasatti (born 1943), Argentine journalist Santo Cilauro (born 1961), Australian comedian, actor, and television producer Santo Condorelli (born 1995), American swimmer Santo Farina (born 1937), American rock and roll musician Santo Jeger (1898–1953), British politician Santo Loquasto (born 1944), American production, set, and costume designer Santo Mazzarino (1916–1987), Italian historian Santo Santoro (born 1956), Australian politician Santo Stephens (born 1969), American football player Santo Trafficante Jr. (1914–1987), American Mafia boss, head of the Trafficante crime family Santo Trafficante Sr. (1886–1954), Sicilian-born mobster, father of Santo Trafficante Jr. Santo Versace (born 1944), Italian businessman and politician
Fictional characters Santo DiMera, a character in Days of Our Lives Rockslide (Santo Vaccarro), Marvel Comics character