Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. They are used in the treatment of hypertension.
Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls.
Class members Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):
Name Image Brand name Citations Amlodipine Norvasc, Istin, Normodipine, Tenox, Cordi Cor Aranidipine Sapresta (サプレスタ) Azelnidipine CalBlock (カルブロック) Barnidipine Vasexten, Libradin, Cyress, HypoCa Benidipine Coniel Cilnidipine Atelec (アテレック), Cilacar, Cinalong, Siscard Clevidipine Cleviprex Cronidipine Darodipine Dexniguldipine Efonidipine Landel (ランデル) Elgodipine Elnadipine Felodipine Renedil, Plendil Flordipine Furnidipine Iganidipine Isradipine DynaCirc CR Lacidipine Lacipil, Motens, Sakure Lemildipine Lercanidipine Zanidip, Zanidip-Recordati Levamlodipine EsCordi Cor Levniguldipine Manidipine Manyper, Caslot, Madipine Nicardipine Cardene, Cardene SR Nifedipine Adalat, Nifedical, Procardia, Corinfar, Cordaflex Niguldipine Niludipine Nilvadipine Nivadil Nimodipine Nimotop Nisoldipine Sular, Baymycard, Syscor Nitrendipine Baypress, Cardif, Nitrepin, Baylotensin Olradipine Oxodipine Palonidipine Pranidipine Acalas Ryodipine Sagandipine Sornidipine Teludipine Tiamdipine Trombodipine Vatanidipine
The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.
See also Calcium channel blocker (including section on non-dihydropyridine calcium channel blockers) Calcium channel Dihydropyridine receptor
References