Stefanos Tsitsipas defeated Andrey Rublev in the final, 6–3, 6–3 to win the singles tennis title at the 2021 Monte-Carlo Masters. It was his first ATP Tour Masters 1000 title, making him the first Greek to win a Masters tournament. Rublev was also in contention for his maiden Masters 1000 title.
Fabio Fognini was the defending champion from when the tournament was last held in 2019, but lost to Casper Ruud in the quarterfinals.
Seeds The top eight seeds received a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Lucky losers
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
References
External links Main draw Qualifying draw