The following is a timeline of the COVID-19 pandemic in Ghana during 2021-2022.

Timeline January 2021 Model-based simulations indicate that the 95% confidence interval for the time-varying reproduction number R t was higher than 1.0 in January.Future scenarios of the healthcare burden of COVID-19 in low- or middle-income countries, MRC Centre for Global Infectious Disease Analysis at Imperial College London. On 1 January, hundreds of worshipers massed up at a chapel defying the COVID-19 safety protocols. Most people in a church in the Central region were not having nose masks on. The president was claimed to have prayed for a COVID-19-free for the country, and hopeful the country would deal with the pandemic in 2021. On 2 January, people gathered at a beach without adhering to the COVID-19 safety protocols. A pastor claimed sermons in the Church would spark up because of the restrictions on religious activities due to the pandemic. The pandemic affected the fashion industry as majority of people use nose masks in their manner of dressing. On 3 January, a nurse warned the public against trying on nose masks before purchasing. The president advised Ghanaians to observe the safety protocols as acquiring the vaccine was being worked on, he also claimed there was no case of the new COVID-19 variant in the country. A pastor held sermons virtually due to COVID-19. On 4 January, the president claimed the country would strengthen its airport restrictions due to the wake of the new variant of COVID-19, he also claimed he would protect students from contracting the virus. Some parents in Koforidua pleaded with the government to absorb fees of students in private schools due to the impact of the pandemic. An association wanted the government to suspend the reopening of the basic school level because of their vulnerability to COVID-19. An association lauded the Government for reopening schools and called on the government to make available the protocols. IMF claimed it spent $11.3billion on Ghana and other countries since the pandemic began last year. The Information Minister provided updates on Ghana's fight against the virus. On 5 January, it was disclosed less than 500 private schools received the government package issued by NBSSI. The president claimed COVID-19 threatened to divert the progress of his administration. Parents asked MoE and GES to provide safety measures before schools reopen. A coalition called on the government to provide the COVID-19 protocols and the quick arrival of PPEs. The GWCL advised consumers to use water productively after the extension of free water package. Zoomlion acquired new vehicles and equipment for fumigation to curb the spread of the virus. On 6 January, the CEO of a company advised business owners to strategize to help the businesses in surviving during the pandemic. Some parents were worried the class size would make it difficult for some schools to observe social distancing. An association were worried the government denied paying salaries to private school teachers during the COVID-19 crisis. An association also claimed about 126 private schools collapsed due to the outbreak of the pandemic. A group were worried schools were to be reopened claiming it might cause the second wave of the pandemic. It was revealed more than 15,200 businesses received financial support from the NBSSI/MasterCard Foundation partnership. A senior lecturer at UG claimed the pandemic should not be a reason the government's inability to fulfil promises made. Some residents in Takoradi/Sekondi were claimed to have no nose mask on in their daily activities. The Annual New Year School program was shortened to 2 days due to COVID-19. Health workers in the Obusi East District were advised to continue the fight against COVID-19. Private schools in Kumasi claimed they were affected by the outbreak of COVID-19. On 7 January, the VP of GMA claimed the government, MoE and GES should close down any school who disregard the safety protocols. The ECG and GWCL activated the supply of electricity and water free of charge to consumers under the COVID-19 relief package. Parents were advised to sensitize their children on the safety protocols. On 8 January, stakeholders in the education sector were encouraged to use online tools and applications to teach SEND children post-COVID-19. The president of an association claimed the hotel industry was watching what was going on in other nations due to COVID-19. It was claimed COVID-19 affected the aviation and tourism sectors in terms of job creation and others. It was also claimed PWDs and other groups were left out in the COVID-19 intervention by the government. On 9 January, a teacher suggested schools should be disinfected on quarterly basis to curb the spread of the virus. An association urged the government to bring about protocols and guidelines for disposal of PPEs for students. On 10 January, it was revealed Ghana and other nations received financial support from IMF. Some parents in Greater Accra region were worried because of the reopening of schools. The management of BTU claimed the institution would adhere to the COVID-19 protocols. On 11 January, an MP cautioned Ghanaians there was an increase in the number of COVID-19 infections. The UK Visa Application Center in Accra shut down their office as the UK was an epic centre for COVID-19. Traders in some areas of Accra stopped the using of hand sanitizers and the putting on of nose masks. Traders in stationery expected more sales after schools were reopened. Health officials cautioned the public to observe the safety protocols in public places etc. Past students of KNUST donated PPEs to an orphanage. On 12 January, GJA appealed to the Presidency consider a stimulus package for journalists due to the pandemic. COVID-19 Taskforce was launched in the Central region to check the pandemic's situation. The president of GMA claimed the non-adherence of the safety protocols caused the rise of COVID-19 in Ghana, it also blamed the Government for letting its guard down, it also warned Ghanaians to observe the safety protocols to avoid a lock down. A coalition of NGOs in health blamed some institutions for not enforcing a policy in their workplace. An MP appealed to the Presidency to consider a COVID-19 relief package for first-year tertiary students. Most people abandoned the putting on of nose masks in the markets of Accra. BTU established a COVID-19 taskforce. An Educationist claimed children are less at risk of contracting the virus. Parents were advised to provide their wards with the necessary PPEs. Bookshop operators claimed their businesses were improving after it was announced schools are to be reopened. The GMA charged the NCCE to start educating the public on the COVID-19 vaccines. On 13 January, some COVID-19 patients complained they were not given food at the Tamale Treatment Centre. FDA denied it has approved a COVID-19 vaccine in Ghana. The Takoradi Veterinary Laboratory claimed it recorded about 30% of tested samples of COVID-19 rate. An officer of GUTA commended the Government for reopening of schools. The president of GMA denied a report made by a newspaper concerning a total lock down. A patient who recovered from the virus advised Ghanaians to abide by the safety protocols. Dealers in nose mask in Accra made sales due to the reopening of schools. The executive director of an institution claimed PPEs do not guarantee protection against the virus. TUC-Ghana advised its members to adhere to the COVID-19 protocols. On 14 January, the GMA claimed Ghana's COVID-19 situation is alarming which might cause rise in cases. Students at TTU were satisfied with the institution's compliance to the safety protocols. An association claimed 51 girls got pregnant because of the shut down of schools due to the pandemic. A US-based Ghanaian cautioned the public to observe the safety protocols. Isolation centers in Ashanti region were reopened due to the increase of inactive cases. It was revealed there was an increase in COVID-19 cases in the Western region. An MP donated face masks to the Municipal Education Directorate in Ho Central. Residents in Aflao claimed they did not benefit from the relief package announced by the government. About 60% of beds in COVID-19 designated centers were claimed to be full. On 15 January, the CEO of a chamber cautioned about the rise in COVID-19 cases and its effects on the health system. UDS launched a five-member COVID-19 response committee. KNUST students praised the safety protocols put in place by the school authorities. An Authority adopted ways to help school owners return to school amidst COVID-19. An Association claimed children who stay at home because of fear of contracting the virus would bring problems. WTA students would receive guidance and counselling prevent them from fears of contracting the virus. The CE of KATH urged the media to tight their advocacy roles for Ghanaians to observe the protocols. Some schools in Akim-Oda claimed they would comply to the safety measures after returning to school. An NGO called for the safeguarding the female child due to the pandemic. Teachers and parents were urged to educate the children on the COVID-19 protocols. Students of UG were advised to be accountable for the compliance of the safety protocols. The GMA appealed to the government to decrease the amount for the COVID-19 test or make it free, and also provision of PPEs to health facilities. An educationist appealed to the government to add teachers to front line workers amid the pandemic. On 16 January, an association intended to audit all schools to establish if PPEs were delivered from the government. The chairperson of the National COVID-19 Trust Fund advised Ghanaians to adhere to the safety protocols. The pandemic was claimed to have affected the registration of marriages in Cape Coast. A market was built temporarily due to COVID-19 to avoid overcrowding in Tema. A headmistress claimed the pandemic affected the academic calendar. The government was blamed for abandoning Ghanaians from the spread of COVID-19. A private university assured parents of safety on campus to avoid the spread of the virus. According to an association, some private schools asked for COVID-19 test results from students. UG-City Campus new students in Accra were said to have disregarded the safety protocols during their registration exercise. A report claimed there was poor observance of the safety protocols by the public and health workers. The Upper West Regional Hospital was among the hospitals selected for the treatment of COVID-19 cases. The administration of TTU adopted a strategy to curb the spread of COVID-19 in the institution. The CEO of KATH praised the media in Ghana for their support to the hospital due to the pandemic. The Ashanti Regional Directorate of Ghana Health Service (GHS) revealed contact tracing would be done to curb the spread of the pandemic. A lecturer at UDS suggested to the GES to run a shift system for basic schools. A hospital in the Western region recorded 30 COVID-19 cases.