Ayles is an English surname. Notable people with the name include:
Adam Ayles (1850–1912), English Arctic explorer Walter Ayles (1879–1953), British Labour Party politician Francis Ayles (1880–1939), Australian cricketer and football umpire Lewis C. Ayles (1927–2009), Canadian politician Eric Ayles (1928–1972), English rugby league footballer Gary Ayles (born 1964), British racing car driver Darryl Ayles (born 1992), Canadian film director