Cassese is a surname. Notable people with the surname include:
Andrew Cassese (born 1972), American actor and musician Antonio Cassese (1937–2011), Italian jurist Cyril Cassese (born 1972), French footballer Kevin Cassese (born 1981), American lacrosse player Sabino Cassese (born 1935), Italian judge and law professor Tom Cassese (born 1946), American football player
See also Joseph Cassese House