Thabethe is a South African Zulu surname that may refer to the following notable people:
Elizabeth Thabethe (1959–2021), Deputy Minister of Tourism in South Africa Nonkhululeko Thabethe (born 1992), South African cricketer Thando Thabethe (born 1990), South African actress and radio presenter Ayanda Gugulethu Thabethe (born 1999), South African beauty pageant titleholder Miss Supranational South Africa 2023 Ayanda Thabethe (born 1986), South African television presenter and entrepreneur