Donnithorne is a surname. Notable people with the surname include:
Audrey Donnithorne (1922–2020), British-Chinese political economist and missionary Don Donnithorne (1926–2016), New Zealand architect Eliza Emily Donnithorne (1821–1886), Australian woman John Donnithorne Taylor (1798–1885), member of the Taylor-Walker brewing family Vyvyan Donnithorne (1886–1968), Archdeacon of Western Szechwan