Plagopterinae is a subfamily of the freshwater fish family Leuciscidae, which contains the true minnows. Members of this family are known as creek chubs or the creek chub-plagopterin (CC-P) clade of minnows. All members of this family are found in North America, and it includes among the northernmost-distributed of all North American minnows, the lake chub.

Genera Couesius D. S. Jordan, 1878 (lake chub) Hemitremia Cope, 1870 (flame chub) Lepidomeda Cope, 1874 (spinedaces) Margariscus Cockerell, 1909 (pearl daces) Meda Girard, 1856 (spikedace) Plagopterus Cope, 1874 (woundfin) Semotilus Rafinesque, 1820 (creek chubs)

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