Edessan, Edessian, or Edessene may refer to:
- in general: someone or something related to the city of Edessa in northern Greece someone or something related to the city of Edessa in southeastern Turkey
- in particular: Edessan Middle Aramaic language, variant term for the Syriac language Edessan Kingdom, ancient kingdom of Osroene, centered in Edessa, modern Turkey Edessan County, a Crusader medieval state, centered in Edessa, modern Turkey Edessan Chronicle, a chronicle written in the 6th century in Edessa, modern Turkey Edessan martyrs, Christian martyrs Shmona and Gurya, martyred in Edessa, modern Turkey Edessan Mandylion, a holy relic in Christian tradition of Edessa, modern Turkey Edessan Ecclesiastical Museum, an ecclesiastical museum in Edessa, Greece Edessan Waterfalls, a waterfall site near Edessa, Greece
See also Edessaikos F.C.