Buffalo Run is a long 3rd order tributary to Sewickley Creek in Westmoreland County, Pennsylvania.
Course Buffalo Run rises at West Bethany, Pennsylvania, and then flows north-northwest to join Sewickley Creek at Hunker.
Watershed Buffalo Run drains of area, receives about 41.5 in/year of precipitation, has a wetness index of 369.10, and is about 48% forested.
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