Cuninghame is a surname, and may refer to:
Polly Cuninghame (c.1785–1837), Dutch dancer Rob Robertson-Cuninghame (1924–2010), Australian pastoralist and academic Robert Cuninghame, 1st Baron Rossmore (1726–1801) was an Irish officer of the British Army and politician Sir Thomas Montgomery-Cuninghame, 10th Baronet (1877–1945), British Army officer William Cuninghame of Lainshaw (c.1775–1849), Scottish landowner and writer on biblical prophecy Sir William Montgomery-Cuninghame, 9th Baronet (1834–1897), British Army officer and politician
See also Cuningham Cunninghame (surname)