Loss Creek may refer to one of several streams:
Canada Loss Creek (British Columbia), in Capital Regional District, British Columbia
United States Loss Creek, in Spring Creek Township, Coffey County, Kansas Loss Creek, in Black Wolf Township, Ellsworth County, Kansas Loss Creek, a river in Ohio Loss Creek, a tributary of the Hiwassee River in Polk County, Tennessee Loss Creek (Texas), in Coleman County, Texas
See also Lost Creek (disambiguation)