Siege of Laodicea can refer to:
Siege of Laodicea (636), capture of Laodicea in Syria (Latakia) by the Rashidun Caliphate Siege of Laodicea (1119), capture of Laodicea in Phrygia by the Byzantine Empire Siege of Laodicea (1188), capture of Laodicea in Syria (Latakia) by the Ayyubid Sultanate Siege of Latakia (2011), suppression of anti-government protests during the Syrian Civil War