Cheshire is a surname, derived from the English county of Cheshire. Notable people with the surname include:

Drew Cheshire (born 1991), English rugby union player Edward Cheshire (c.1841–1919), British brewer and Mayor of Smethwick Elizabeth Cheshire (born 1967), American actress Fleming D. Cheshire (1849–1922), American businessman, interpreter, and diplomat Geoffrey Cheshire (1886–1978), British barrister, scholar, and writer Godfrey Cheshire (born 1951), American film critic, film writer, and director Harry Cheshire (1891–1968), American actor Ian Cheshire (engineer) (1936–2013), Scottish petroleum engineer Ian Cheshire (businessman) (born 1959), British businessman Jenny Cheshire, British sociolinguist and professor John Cheshire (RAF officer) (born 1942), British retired senior Royal Air Force commander John Cheshire (boxer) (born 1947), British boxer John Cheshire (rugby league) (1933–2024), Welsh rugby league footballer Joseph Blount Cheshire (1850–1932), American Episcopal bishop of North Carolina, US Leonard Cheshire (1917–1992), British World War II RAF pilot and philanthropist Lorraine Cheshire (1960–2025), English actress Maxine Cheshire (1930–2020), American newspaper reporter Oliver Cheshire (born 1988), English fashion model and writer Pip Cheshire (1950–2026), New Zealand architect Rowan Cheshire (born 1995), British freestyle skier Simon Cheshire (born 1964), British author of children's literature Stuart Cheshire, computer scientist and programmer at Apple