The 2021 Cleveland Indians season was the 121st season for the franchise. It was the ninth season under the leadership of manager Terry Francona and sixth under general manager Mike Chernoff. The Indians played their home games at Progressive Field in Cleveland, Ohio.
This was the team's final season under the name Indians. Following the season, the team became known as the Cleveland Guardians after decades of controversy surrounding the "Indians" name.
The Indians made MLB history by becoming the first team to be no-hit three times in a single season. Those three no-hitters came off of Carlos Rodón of the Chicago White Sox on April 14, Wade Miley of the Cincinnati Reds on May 7, and Corbin Burnes and Josh Hader of the Milwaukee Brewers on September 11. By coincidence, Zach Plesac was their starting pitcher in all three no-hitters. In addition, they were held hitless in a seven-inning doubleheader game against the Tampa Bay Rays.
Season standings
American League Central
American League Wild Card
Record against opponents
Game log
Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed --> |- style="background:#fbb | 1 || April 1 || @ Tigers || 2–3 || Boyd (1–0) || Bieber (0–1) || Soto (1) || 8,000 || 0–1 || L1 |- style="background:#fbb | 2 || April 3 || @ Tigers || 2–5 || Teherán (1–0) || Plesac (0–1) || Garcia (1) || 8,000 || 0–2 || L2 |- style="background:#bfb | 3 || April 4 || @ Tigers || 9–3 || Civale (1–0) || Norris (0–1) || || 8,000 || 1–2 || W1 |- style="background:#fbb | 4 || April 5 || Royals || 0–3 || Duffy (1–0) || Allen (0–1) || Hahn (1) || 8,914 || 1–3 || L1 |- style="background:#bfb | 5 || April 7 || Royals || 4–2 || Clase (1–0) || Holland (0–1) || Wittgren (1) || 5,908 || 2–3 || W1 |- style="background:#bfb | 6 || April 9 || Tigers || 4–1 || Plesac (1–1) || Holland (0–1) || Clase (1) || 7,775 || 3–3 || W2 |- style="background:#bfb | 7 || April 10 || Tigers || 11–3 || Civale (2–0) || Skubal (0–1) || || 7,570 || 4–3 || W3 |- style="background:#bfb | 8 || April 11 || Tigers || 5–2 || Allen (1–1) || Urena (0–2) || Clase (2) || 6,859 || 5–3 || W4 |- style="background:#fbb | 9 || April 12 || @ White Sox || 3–4 || Heuer (1–0) || Clase (1–1) || || 7,393 || 5–4 || L1 |- style="background:#bfb | 10 || April 13 || @ White Sox || 2–0 || Bieber (1–1) || Crochet (0–2) || Karinchak (1) || 7,102 || 6–4 || W1 |- style="background:#fbb;" | 11 || April 14 || @ White Sox || 0–8 || Rodón (2–0) || Plesac (1–2) || || 7,148 || 6–5 || L1 |- style="background: #bfb | 12 || April 15 || @ White Sox || 4–2 || Civale (3–0) || Lynn (1–1) || Clase (3) || 7,049 || 7–5 || W1 |- style="background:#fbb | 13 || April 16 || @ Reds || 3–10 || Hoffman (2–1) || Allen (1–2) || || 12,497 || 7–6 || L1 |- style="background:#fbb | 14 || April 17 || @ Reds || 2–3 || Doolittle (2–0) || Pérez (0–1) || || 12,598 || 7–7 || L2 |- style="background:#bfb | 15 || April 18 || @ Reds || 6–3 || Bieber (2–1) || Miley (2–1) || Clase (4) || 12,551 || 8–7 || W1 |- style="background:#fbb | 16 || April 20 || White Sox || 5–8 || Rodón (3–0) || Plesac (1–3) || || 4,176 || 8–8 || L1 |- style="background: #bbb | — || April 21 || White Sox || colspan=7 | Postponed (rain) make-up date May 31 |- style="background:#fbb | 17 || April 22 || Yankees || 3–6 || Germán (1–2) || Wittgren (0–1) || Chapman (3) || 6,380 || 8–9 || L2 |- style="background:#fbb;" | 18 || April 23 || Yankees || 3–5 || Luetge (1–0) || Allen (1–3) || Chapman (4) || 8,662 || 8–10 || L3 |- style="background:#fbb | 19 || April 24 || Yankees || 1–2 || Cole (3–1) || Bieber (2–2) || Loáisiga (1) || 8,817 || 8–11 || L4 |- style="background:#bfb | 20 || April 25 || Yankees || 7–3 || Hentges (1–0) || Taillon (0–2) || || 8,766 || 9–11 || W1 |- style="background:#bfb | 21 || April 26 || Twins || 5–3 || Clase (2–1) || Colomé (1–3) || || 4,555 || 10–11 || W2 |- style="background:#bfb | 22 || April 27 || Twins || 7–4 || Civale (4–0) || Maeda (1–2) || Karinchak (2) || 6,303 || 11–11 || W3 |- style="background:#fbb | 23 || April 28 || Twins || 2–10 || Happ (2–0) || Allen (1–4) || || 5,903 || 11–12 || L1 |- style="background:#bfb | 24 || April 30 || @ White Sox || 5–3 || Bieber (3–2) || Keuchel (1–1) || Clase (5) || 9,405 || 12–12 || W1
Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed --> |- style="background:#fbb | 25|| May 1 || @ White Sox || 3–7 || Lynn (2–1) || McKenzie (0–1) || || 9,451 || 12–13 || L1 |- style="background:#bfb | 26 || May 2 || @ White Sox || 5–0 || Plesac (2–3) || Giolito (1–3) || || 9,471 || 13–13 || W1 |- style="background:#bfb | 27 || May 3 || @ Royals || 8–6 || Shaw (1–0) || Junis (1–2) || Clase (6) || 6,919 || 14–13 || W2 |- style="background:#bfb | 28 || May 4 || @ Royals || 7–3 || Wittgren (1–1) || Staumont (0–1) || || 5,997 || 15–13 || W3 |- style="background:#bfb | 29 || May 5 || @ Royals || 5–4 || Wittgren (2–1) || Davis (0–1) || Karinchak (3) || 9,640 || 16–13 || W4 |- style="background:#bfb | 30 || May 6 || @ Royals || 4–0 || McKenzie (1–1) || Duffy (4–2) || || 9,259 || 17–13 || W5 |- style="background:#fbb | 31 || May 7 || Reds || 0–3 || Miley (4–2) || Clase (2–2) || || 7,803 || 17–14 || L1 |- style="background:#bfb | 32 || May 8 || Reds || 9–2 || Civale (5–0) || Castillo (1–4) || || 9,968 || 18–14 || W1 |- style="background:#bbb | — || May 9 || Reds || colspan=7 | Postponed (rain) make-up date August 9 |- style="background:#bfb | 33 || May 11 || Cubs || 3–2 || Bieber (4–2) || Alzolay (1–3) || Clase (7) || 8,024 || 19–14 || W2 |- style="background:#bfb | 34 || May 12 || Cubs || 2–1 || Karinchak (1–0) || Thompson (1–1) || — || 8,589 || 20–14 || W3 |- style="background:#bfb | 35 || May 13 || @ Mariners || 4–2 || Plesac (3–3) || Gilbert (0–1) || Shaw (1) || 9,880 || 21–14 || W4 |- style="background:#fbb | 36 || May 14 || @ Mariners || 3–7 || Flexen (4–1) || Civale (5–1) || Montero (5) || 10,014 || 21–15 || L1 |- style="background:#fbb | 37 || May 15 || @ Mariners || 3–7 || Sheffield (3–3) || McKenzie (1–2) || || 10,311 || 21–16 || L2 |- style="background:#fbb | 38 || May 16 || @ Mariners || 2–3 || Sewald (1–0) || Bieber (4–3) || Graveman (5) || 10,287 || 21–17 || L3 |- style="background:#fbb | 39 || May 17 || @ Angels || 4–7 || Watson (2–1) || Hentges (1–1) || Iglesias (7) || 9,527 || 21–18 || L4 |- style="background:#bfb | 40 || May 18 || @ Angels || 6–5 || Plesac (4–3) || Claudio (0–1) || Karinchak (4) || 9,491 || 22–18 || W1 |- style="background:#bfb | 41 || May 19 || @ Angels || 3–2 || Civale (6–1) || Watson (2–2) || Karinchak (5) || 10,378 || 23–18 || W2 |- style="background:#fbb | 42 || May 21 || Twins || 0–10 || Dobnak (1–3) || McKenzie (1–3) || — || 11,675 || 23–19 || L1 |- style="background:#bfb | 43 || May 22 || Twins || 5–3 || Karinchak (2–0) || Colomé (2–4) || — || 11,505 || 24–19 || W1 |- style="background:#fbb | 44 || May 23 || Twins || 5–8 || Robles (1–1) || Karinchak (2–1) || Duffey (1) || 9,805 || 24–20 || L1 |- style="background:#bfb | 45 || May 24 || @ Tigers || 6–5 || Mejía (1–0) || Garcia (0–1) || Clase (8) || 7,832 || 25–20 || W1 |- style="background:#bfb | 46 || May 25 || @ Tigers || 4–0 || Civale (7–1) || Skubal (1–7) || Karinchak (6) || 8,000 || 26–20 || W2 |- style="background:#fbb | 47 || May 26 || @ Tigers || 0–1 || Fulmer (4–3) || Quantrill (0–1) || Soto (5) || 7,525 || 26–21 || L1 |- style="background:#bfb | 48|| May 27 || @ Tigers || 5–2 || Bieber (5–3) || Boyd (2–6) || — || 8,000 || 27–21 || W1 |- style="background:#fbb | 49 || May 28 || Blue Jays || 2–11 || Ryu (5–2) || Morgan (0–1) || — || 9,198 || 27–22 || L1 |- style="background:#bbb | — || May 29 || Blue Jays || colspan=7 | Postponed (high winds) make-up date May 30 |- style="background:#fbb | 50 || May 30 || Blue Jays || 1–4 || Stripling (1–3) || Civale (7–2) || Romano (3) || — || 27–23 || L2 |- style="background:#bfb | 51 || May 30 || Blue Jays || 6–5 || Clase (3–2) || Chatwood (0–2) || — || 11,690 || 28–23 || W1 |- style="background:#fbb | 52 || May 31 || White Sox || 6–8 || Heuer (4–1) || Karinchak (2–2) || Bummer (1) || — || 28–24 || L1 |- style="background:#bfb | 53 || May 31 || White Sox || 3–1 || Maton (1–0) || Lambert (0–1) || Clase (9) || 10,726 || 29–24 || W1
Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed --> |- style="background:#bfb | 54 || June 1 || White Sox || 6–5 || Bieber (6–3) || Cease (3–2) || Karinchak (7) || 7,132 || 30–24 || W2 |- style="background:#bbb | — || June 2 || White Sox || colspan=7 | Postponed (rain) make-up date September 23 |- style="background:#fbb | 55 || June 4 || @ Orioles || 1–3 || Sulser (2–0) || Shaw (1–1) || Fry (2) || 12,009 || 30–25 || L1 |- style="background:#bfb | 56 || June 5 || @ Orioles || 10–4 || Civale (8–2) || Means (4–2) || || 9,969 || 31–25 || W1 |- style="background:#fbb | 57 || June 6 || @ Orioles || 5–18 || López (2–6) || Quantrill (0–2) || || 9,423 || 31–26 || L1 |- style="background:#bfb | 58 || June 8 || @ Cardinals || 10–1 || Bieber (7–3) || Martínez (3–6) || || 16,178 || 32–26 || W1 |- style="background:#fbb | 59 || June 9 || @ Cardinals || 2–8 || Wainwright (4–5) || Mejía (0–1) || || 16,331 || 32–27 || L1 |- style="background:#bfb | 60 || June 11 || Mariners || 7–0 || Civale (9–2) || Dunn (1–3) || || 22,970 || 33–27 || W1 |- style="background:#bfb | 61 || June 12 || Mariners || 5–4 || Karinchak (3–2) || Sewald (2–2) || || 20,116 || 34–27 || W2 |- style="background:#fbb | 62 || June 13 || Mariners || 2–6 || Gilbert (2–2) || Bieber (7–4) || || 17,371 || 34–28 || L1 |- style="background:#bfb | 63 || June 14 || Orioles || 4–3 || Sandlin (1–0) || Kremer (3–6) || Clase (10) || 11,181 || 35–28 || W1 |- style="background:#bfb | 64 || June 15 || Orioles || 7–2 || Karinchak (4–2) || Harvey (3–8) || || 12,025 || 36–28 || W2 |- style="background:#bfb | 65 || June 16 || Orioles || 8–7 || Civale (10–2) || Akin (0–2) || Clase (11) || 12,825 || 37–28 || W3 |- style="background:#bfb | 66 || June 17 || Orioles || 10–3 || Stephan (1–0) || López (2–8) || — || 15,121 || 38–28 || W4 |- style="background:#fbb | 67 || June 18 || @ Pirates || 10–11 || Kuhl (1–4) || Mejía (1–2) || Rodriguez (8) || 16,965 || 38–29 || L1 |- style="background:#fbb | 68 || June 19 || @ Pirates || 3–6 || Stratton (2–0) || Shaw (1–2) || — || 16,830 || 38–30 || L2 |- style="background:#bfb | 69 || June 20 || @ Pirates || 2–1 || Maton (2–0) || Brubaker (4–6) || Karinchak (8) || 16,582 || 39–30 || W1 |- style="background:#bfb | 70 || June 21 || @ Cubs || 4–0 || Shaw (2–2) || Alzolay (4–6) || || 32,934 || 40–30 || W2 |- style="background:#fbb | 71 || June 22 || @ Cubs || 1–7 || Hendricks (10–4) || Morgan (0–2) || || 35,493 || 40–31 || L1 |- style="background:#bfb | 72 || June 24 || @ Twins || 4–1 || Parker (1–0) || Alcalá (1–2) || Karinchak (9) || 18,812 || 41–31 || W1 |- style="background:#fbb | 73 || June 25 || @ Twins || 7–8 || Jax (1–0) || Wittgren (2–2) || Robles (7) || 16,892 || 41–32 || L1 |- style="background:#bbb | — || June 26 || @ Twins || colspan=7 | Postponed (rain) make-up date September 14 |- style="background:#fbb | 74 || June 27 || @ Twins || 2–8 || Happ (4–3) || Hentges (1–2) || || 20,215 || 41–33 || L2 |- style="background:#bfb | 75 || June 28 || Tigers || 13–5 || Morgan (1–2) || Manning (1–2) || || 13,128 || 42–33 || W1 |- style="background:#bbb | — || June 29 || Tigers || colspan=7 | Postponed (rain) make-up date June 30 |- style="background:#fbb | 76 || June 30 || Tigers || 4–9 || Funkhouser (2–0) || Shaw (2–3) || || — || 42–34 || L1 |- style="background:#fbb | 77 || June 30 || Tigers || 1–7 || Peralta (1–1) || Allen (1–5) || || 11,627 || 42–35 || L2
Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed --> |- style="background:#fbb | 78 || July 1 || Astros || 2–7 || Valdez (5–1) || Mejía (1–3) || || 13,772 || 42–36 || L3 |- style="background:#fbb | 79 || July 2 || Astros || 3–6 || McCullers Jr. (6–1) || Hentges (1–3) || Pressly (13) || 24,337 || 42–37 || L4 |- style="background:#fbb