Ayer House may refer to:
Alfred Ayer House, Oklawaha, Florida Thomas R. Ayer House, Oklawaha, Florida Caleb R. Ayer House, Cornish, Maine Albert Ayer House, Winchester, Massachusetts Thomas Ayer House, Winchester, Massachusetts W. B. Ayer House, Portland, Oregon, listed on the National Register of Historic Places Ayer–Shea House, Portland, Oregon