Pepillo is a pet form of the Spanish name José. Pepillo may refer to:
People Pepillo Salcedo (1816–1814), head of state of the Dominican Republic Pepillo Salcedo, Dominican Republic, municipality in the Dominican Republic named after the head of state Pepillo Romero (born 1878), Cuban baseball player Pepillo (footballer, born 1916), Spanish footballer born José Díaz Payán Pepillo (footballer, born 1934), Spanish footballer born José García Castro Pepillo, central character in the 2009 television film Expecting a Miracle