Trelles is a surname. Notable people with the surname include:
Augusto Barcía Trelles (1881–1961), Spanish politician, briefly acting Prime Minister of Spain Efraín Trelles (1953–2018), Peruvian historian, writer, journalist and sports commentator Gustavo Trelles (born 1955), Uruguayan former rally driver Ignacio Trelles (1916–2020), Mexican football player and coach Norbert Trelle (born 1942), German Roman Catholic bishop Rafael Trelles (born 1957), Puerto Rican artist
See also José Alonso y Trelles (1857–1924), Uruguayan poet