Senator Clarke may refer to:
Members of the United States Senate James Paul Clarke (1854–1916), U.S. Senator from Arkansas from 1903 to 1916 John Hopkins Clarke (1789–1870), U.S. Senator from Rhode Island from 1847 to 1853
United States state senate members Archibald S. Clarke (1788–1821), New York State Senate Eugene Clarke (born 1956), Mississippi State Senate Frank Gay Clarke (1850–1901), New Hampshire State Senate George L. Clarke (1813–1890), Rhode Island State Senate George W. Clarke (Washington politician) (1906–2006), Washington State Senate Hansen Clarke (born 1957), Michigan State Senate James M. Clarke (1917–1999), North Carolina State Senate John Blades Clarke (1833–1911), Kentucky State Senate John Jones Clarke (1803–1887), Massachusetts State Senate John Clarke (Michigan politician) (1797–1876), Michigan State Senate Kathryn Clarke (politician) (1873–1940), Oregon State Senate S. D. Clarke (1881–1966), Florida State Senate Terrel E. Clarke (1920–1997), Illinois State Senate