Kirker is a surname. Notable people with the surname include:
Harold Kirker (1921–2018), American historian James Kirker (1793–1852), Irish-born American privateer, soldier, mercenary, merchant, and scalp hunter Marion Kirker (1879–1971), New Zealand photographer Thomas Kirker (1760–1837), American politician William Kirker (1866–1942), New Zealand cricketer William C. Kirker, namesake of Kirkersville, Ohio
Given name Kirker Butler, American television writer